Cannabidiol (CBD) is one of the non-psychoactive cannabinoids obtained from the cannabis plant. This chemical compound acts as a regulator of oxidative stress and inflammation in peripheral tissues and the central nervous system, thus restoring the balance of our cellular systems.

Cannabinoids are organic chemical compounds that can be categorized according to their origin; phytocannabinoids, such as CBD, CBG, CBN that are produced by plants, and endocannabinoids, such as anandamide (N-arachidonoylethanolamide, ANA) and 2-arachidonylglycerol (2-AG) that are produced by mammals.


Cannabinoids help regulate aspects such as appetite, mood, pain perception, memory, concentration, among others.

 

CBD interacts with the Endocannabinoid System which is made up of receptors, enzymes and ion channels distributed throughout the body. This system, present in the body of mammals, consists of two types of receptors for certain cannabinoids, CB1 and CB2.

CBD as a sole treatment or as an adjunct to pharmacological therapy, has shown an improvement in the quality of life of treated patients.


Cannabinoids are becoming the basis for a new generation of drugs that offer the opportunity to effectively and safely expand the treatment of conditions such as:
Chronic and acute pain, insomnia, Parkinson's, multiple sclerosis, anxiety, arthritis and rheumatism, epilepsy, seizures, cancer and neurodegenerative diseases.

Some cannabinoids are available in different ways to be administered and are designed according to the needs and conditions of the patient. Pharmaceutical forms are all those presentations in which we find a medicine available, for example: tablets, syrups, capsules, suppositories, patches, etc


The way cannabinoids move through the body (pharmacokinetics) varies according to the route of administration of the product. The duration of the therapeutic effect will depend on the dose, the pharmaceutical form and the route of administration. The most common routes of administration are:


• Inhalation route: medications that are administered by inhalation (nebulizers, vaporizers) are rapidly absorbed in the lungs.
Advantages: High concentrations are reached in the bloodstream and effects are seen within the first 10 minutes after being absorbed.
Disadvantages: High concentrations of some cannabinoids could trigger unwanted side effects. Likewise, the metabolism is fast and the duration of the effect is relatively short.


• Oral route: are all those forms that are administered through the oral cavity and that involve swallowing the product. The absorption of cannabinoids takes place in the gastro-intestinal tract (mouth, esophagus, stomach, intestines). The main pharmaceutical forms available for oral administration are oils (oily solutions), sprays, capsules, tablets and other foods such as gummies, galeas, gels, etc.
Advantages: Knowledge of the administered dose. Pharmaceutical grade products are standardized, this means that the products contain the same dose every time regardless of the manufacturing lot. The effects are long lasting, compared to the inhalation route, and the ease of handling unwanted adverse events.
Disadvantages: The time between administration and absorption of cannabinoids into the bloodstream is between 45 minutes and up to 3 hours.


• Sublingual route: The product (generally oily solutions or special tablets) is placed under the tongue and left to rest for between 30 and 60 seconds so that it is absorbed in the area and passes directly into the bloodstream.
Advantages: It is a direct absorption, it takes between 1 and 3 minutes to perceive the effect in this way. In addition, by not having contact with the digestive system, the molecules arrive better integrated into the bloodstream, since they are not exposed to gastric juices or to liver processing. It is usually used for children or elderly patients who cannot swallow.
Disadvantages: Interferes with eating, drinking, and speaking and only allows administration of small doses.


• Transdermal/topical route: In this route of administration, cannabinoids are applied to the surface of the skin or to the mucous membranes to be absorbed. The vast majority of these products are for local use (creams, gels, ointments, lotions), that is, they have an effect on the area where they are applied, although currently they work with patches that adhere to the surface of the skin and they are able to release cannabinoids into the bloodstream and have a systemic effect.

Advantages: Knowledge of the administered dose. Pharmaceutical grade products are standardized, this means that the products contain the same dose every time regardless of the manufacturing lot. The effects are long lasting, compared to the inhalation route, and the ease of handling unwanted adverse events.
Disadvantages: The time between administration and absorption of cannabinoids into the bloodstream is between 45 minutes and up to 3 hours.

• Sublingual route: The product (generally oily solutions or special tablets) is placed under the tongue and left to rest for between 30 and 60 seconds so that it is absorbed in the area and passes directly into the bloodstream.
Advantages: It is a direct absorption, it takes between 1 and 3 minutes to perceive the effect in this way. In addition, by not having contact with the digestive system, the molecules arrive better integrated into the bloodstream, since they are not exposed to gastric juices or to liver processing. It is usually used for children or elderly patients who cannot swallow.
Disadvantages: Interferes with eating, drinking, and speaking and only allows administration of small doses.


• Transdermal/topical route: In this route of administration, cannabinoids are applied to the surface of the skin or to the mucous membranes to be absorbed. The vast majority of these products are for local use (creams, gels, ointments, lotions), that is, they have an effect on the area where they are applied, although currently they work with patches that adhere to the surface of the skin and they are able to release cannabinoids into the bloodstream and have a systemic effect.

We have the medical support of more than 200 health professionals and the means to channel the patient to personalized consultations. We invest in scientific and technological research and development to offer safe products for the patient. At Somalab, our priority is the patient's state of homeostasis.


Quality and Safety
The quality of cannabinoid medicines can vary greatly. This poses risks and uncertainty to patients and the health professionals who prescribe them. So why is quality important?


Cannabinoids have been used in human clinical studies and have been shown to be relatively safe for most people compared to other medications. Absolute safety does not exist for any medicine. All medicines have a risk that can trigger the appearance of adverse and secondary effects. In particular, large doses of THC and other potent synthetic cannabinoids have been shown to have a high risk of harm, for example, acute postural hypotension or mild to moderate psychotic events.


The safest and most reliable products are those of pharmaceutical quality. These products are manufactured under the standards of Good Manufacturing Practices (GMP). The GMP is the highest manufacturing standard for pharmaceutical products and is a certificate of the high quality of the products and their manufacturing processes.


Quality and Trust
All medicines must have a clearly defined composition. SOMALAB products contain a constant composition of active ingredients between each batch, which ensures that the patient can consume the same dose every time.


Doctors and health professionals in charge of prescribing cannabinoid medications are the best trained personnel to monitor the effects of the doses and to be able to prevent unwanted adverse effects.
SOMALAB products are subjected to a strict quality analysis to identify the cannabinoids present; the absence or presence of microorganisms, pesticides, heavy metals, residual solvents, mycotoxins and other contaminants that can affect the quality of the products